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        <p>\n
        \tCentrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;s seg&iacute;ts&eacute;g&eacute;vel lapatinib tartalm&uacute; amorf diszperzi&oacute;t siker&uuml;lt el&#337;&aacute;ll&iacute;taniuk a Sapientia EMTE &eacute;s az Erd&eacute;lyi M&uacute;zeum-Egyes&uuml;let kutat&oacute;csoportj&aacute;nak a Magyar Tudom&aacute;nyos Akad&eacute;mia Domus-csoportos kutat&aacute;si projekt t&aacute;mogat&aacute;s&aacute;val. A lapatinib a r&aacute;k kezel&eacute;s&eacute;ben gyakran alkalmazott gy&oacute;gyszer; korl&aacute;tozott oldhat&oacute;s&aacute;ga &eacute;s permeabilit&aacute;sa miatt azonban a ter&aacute;pi&aacute;s d&oacute;zis el&eacute;r&eacute;se or&aacute;lis adagol&aacute;ssal kih&iacute;v&aacute;st jelentett.<p>\n
        \t<strong>Centrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;s seg&iacute;ts&eacute;g&eacute;vel siker&uuml;lt el&#337;&aacute;ll&iacute;tani lapatinib-tartalm&uacute; amorf diszperzi&oacute;t</strong></p><p>\n
        \tA Lapatinib (Lap) egy lipofil hat&oacute;anyag, melyet az el&#337;rehaladott vagy &aacute;tt&eacute;tes HER2+ eml&#337;r&aacute;k eset&eacute;ben alkalmaznak kapecitabinnal vagy letrozollal kombin&aacute;lva. Tov&aacute;bb&aacute; a Lap lipofil tulajdons&aacute;g&aacute;nak k&ouml;sz&ouml;nhet&#337;en k&ouml;nnyen &aacute;thatol a v&eacute;r-agy g&aacute;ton, minek k&ouml;sz&ouml;nhet&#337;en egy potenci&aacute;lis megold&aacute;s lehet az agyr&aacute;k kezel&eacute;s&eacute;ben. A hat&oacute;anyag lipofil tulajdons&aacute;ga azonban mag&aacute;val vonja a gyenge oldhat&oacute;s&aacute;got vizes k&ouml;rnyezetben, minek k&ouml;vetkezt&eacute;ben a hat&oacute;anyag old&oacute;d&aacute;sa az emberi szervezetben neh&eacute;zkes. Az oldhat&oacute;s&aacute;g n&ouml;vel&eacute;s&eacute;re t&ouml;bb megold&aacute;s l&eacute;tezik, viszont a polimer sz&aacute;lakba &aacute;gyazott hat&oacute;anyaghordoz&oacute; rendszerek nagy figyelmet kapnak a szakirodalomban. Polimer sz&aacute;lak el&#337;&aacute;ll&iacute;t&aacute;s&aacute;ra a leggyakrabban haszn&aacute;lt m&oacute;dszer az elektrosztatikus sz&aacute;lk&eacute;pz&eacute;s. Hab&aacute;r az elj&aacute;r&aacute;snak t&ouml;bb h&aacute;tr&aacute;nya is van, mint p&eacute;ld&aacute;ul az alacsony kihozatal (termel&eacute;kenys&eacute;g), a magas elektromos t&eacute;r haszn&aacute;lat, a haszn&aacute;lt oldat elektromosan vezet&#337; kell legyen, m&eacute;gis el&#337;szeretettel alkalmazz&aacute;k, mivel viszonylag kis mennyis&eacute;g&#369; oldatb&oacute;l m&aacute;r sz&aacute;lat lehet l&eacute;trehozni.<br>\n
        \tA sz&aacute;lgy&aacute;rt&aacute;s termel&eacute;kenys&eacute;g&eacute;nek n&ouml;vel&eacute;s&eacute;re az elektrosztatikus sz&aacute;lk&eacute;pz&eacute;st haszn&aacute;lva sz&aacute;mos megold&aacute;s l&eacute;tezik m&aacute;r, viszont az oldat vezet&#337;k&eacute;pess&eacute;ge &eacute;s a magas elektromos t&eacute;r alkalmaz&aacute;sa tov&aacute;bbra is h&aacute;tr&aacute;ny marad, nem besz&eacute;lve a sk&aacute;l&aacute;z&aacute;sb&oacute;l k&ouml;vetkez&#337; probl&eacute;m&aacute;kr&oacute;l. A centrifug&aacute;lis sz&aacute;lk&eacute;pz&#337; elj&aacute;r&aacute;s nem haszn&aacute;l elektromos teret a sz&aacute;lk&eacute;pz&eacute;shez &eacute;s magas termel&eacute;kenys&eacute;get biztos&iacute;t, &iacute;gy egy potenci&aacute;lis sk&aacute;l&aacute;z&aacute;si sz&aacute;lk&eacute;pz&eacute;si technol&oacute;gia. A centrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;s sor&aacute;n a hat&oacute;anyag hat&aacute;sa az oldat elektromos vezet&#337;k&eacute;pess&eacute;g&eacute;re nem jelent t&ouml;bb&eacute; probl&eacute;m&aacute;t, szemben az elektrosztatikus sz&aacute;lk&eacute;pz&#337; elj&aacute;r&aacute;ssal.<br>\n
        \tA kutat&aacute;s h&aacute;rom int&eacute;zm&eacute;ny egy&uuml;ttm&#369;k&ouml;d&eacute;se &aacute;ltal val&oacute;sult meg: az Erd&eacute;lyi M&uacute;zeum-Egyes&uuml;let, a Sapientia Erd&eacute;lyi Magyar Tudom&aacute;nyegyetem, illetve a Marosv&aacute;s&aacute;rhelyi &bdquo;George Emil Palade" Orvosi, Gy&oacute;gyszer&eacute;szeti, Tudom&aacute;ny- &eacute;s Technol&oacute;giai Egyetem. Az MTA Domus csoportos kutat&aacute;si p&aacute;ly&aacute;zata r&eacute;v&eacute;n siker&uuml;lt el&#337;&aacute;ll&iacute;tani centrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;ssel Lap tartalm&uacute; sz&aacute;las hat&oacute;anyaghordoz&oacute; rendszert, szisztematikusan tanulm&aacute;nyozva a centrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;si param&eacute;tereket a folyamat optimaliz&aacute;l&aacute;sa &eacute;rdek&eacute;ben. A kiold&oacute;d&aacute;si eredm&eacute;nyeket &ouml;sszehasonl&iacute;tottuk az el&#337;z&#337;ekben publik&aacute;lt elektrosztatikus sz&aacute;lk&eacute;pz&eacute;ssel el&#337;&aacute;ll&iacute;tott rendszerrel, kimutatva, hogy a centrifug&aacute;lis sz&aacute;lk&eacute;pz&eacute;ssel &eacute;s elektrosztatikus sz&aacute;lk&eacute;pz&eacute;ssel el&#337;&aacute;ll&iacute;tott rendszer k&ouml;zt a Lap kiold&oacute;d&aacute;s&aacute;t tekintve nincs k&uuml;l&ouml;nbs&eacute;g. Az eredm&eacute;nyek t&uuml;kr&eacute;ben a centrifug&aacute;lis szakk&eacute;pz&eacute;ssel, 12,2 g/h, k&eacute;t nagys&aacute;grenddel nagyobb kihozatalt &eacute;rt&uuml;nk el az elektrosztatikus sz&aacute;lk&eacute;pz&eacute;shez k&eacute;pest, 0,11 g/h.</p><p>\n
        \t<strong>A tanulm&aacute;ny itt &eacute;rhet&#337; el:</strong></p><p>\n
        \tEnik&#337; Bitay, Attila Levente Gergely, J&oacute;zsef K&aacute;ntor, Zolt&aacute;n-Istv&aacute;n Szab&oacute;: <em>Evaluation of Lapatinib-Loaded Microfibers Prepared by Centrifugal Spinning</em>. Polymers 14, no. 24 (2022): 5557.<br>\n
        \t<a href="https://doi.org/10.3390/polym14245557">https://doi.org/10.3390/polym14245557</a></p><p>\n
        \t&nbsp;</p></p>\n
        """
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